At the AAG 2022 annual meeting, the Symposium on Data-Intensive Understanding in the Era of AI and CyberGIS will be held by building on the successes of previous Symposia focused on cyberGIS and geospatial data science at AAG annual meetings since 2011. A suite of paper and panel sessions will address cutting-edge advances of cyberGIS, geospatial AI and data science, and fundamental geospatial understanding derived from spatial and spatiotemporal data synthesis. The topical themes of the symposium will include, but are not limited to, frontiers of cyberGIS, geospatial AI and data science, data-intensive geography, high-performance computing approaches to geographic problem solving, computational reproducibility and replicability for data-intensive geospatial understanding, geographic approaches to resilience and sustainability challenges enabled by AI and cyberGIS, human-centered decision making, and challenges and opportunities of education and workforce development in harnessing the geospatial data revolution.